--- title: "Solutions" description: "" url: "https://www.onesumportal.com/solutions" date: "2026-06-22T17:10:19+00:00" language: "en-GB" --- ### ICHS1B(R1) Analysis and Report Preparation We offer **AI-assisted, expert-driven ICH S1B(R1) carcinogenicity assessments** aligned with the current regulatory guideline. Our **AI-supported workflows** streamline data gathering and evaluation, enabling a **comprehensive, weight-of-evidence approach** that integrates literature, preclinical data, mechanistic insights, ‘omics datasets and regulatory documentation. Combined with expert review, this approach delivers robust, **regulator-ready carcinogenicity reports** grounded in scientific rigor and reproducibility. You can read more about these approaches and solutions in the following articles: - [ ICH S1B(R1) Guideline and AI-Enabled Approaches ](https://www.onesumportal.com/articles-news/articles/ich-s1b-r1-guideline-and-ai-enabled-approaches) - [ What is Onesum? ](https://www.onesumportal.com/articles-news/articles/what-is-onesum) ### Target Safety Assessment Our **AI-enabled target safety assessment workflows** integrate advanced automation with expert toxicological interpretation to identify and evaluate potential safety risks associated with target modulation. Leveraging AI for intelligent data extraction and analysis, we combine **peer-reviewed literature, prescribing information, regulatory documentation, omics datasets (e.g., genomics and proteomics), and cheminformatics resources** into a unified evaluation framework. **This AI-driven, expert-led approach** enables early detection of on-target and off-target risks, supporting **informed decision-making and proactive risk mitigation** throughout the development lifecycle. You can read more about these approaches and solutions in the following articles: - [ Target Safety Assessment ](https://www.onesumportal.com/articles-news/articles/target-safety-assessment) - [ What is Onesum? ](https://www.onesumportal.com/articles-news/articles/what-is-onesum) ### Safety Limit Derivation (including PDEs) We apply **AI-assisted workflows** to accelerate and improve the derivation of safe exposure limits, including PDEs. Our AI-assisted, expert-driven approach supports rapid literature analysis and data evaluation, providing a **transparent and reproducible foundation** for expert toxicological interpretation. The outcome is a **scientifically robust, regulator-ready assessment**, reviewed and signed by our European Registered Toxicologist (ERT). You can read more about these approaches and solutions in the following articles: - [ LLMs & Safety Limits in Toxicology ](https://www.onesumportal.com/articles-news/articles/llms-safety-limits-in-toxicology) - [ The Central Role of Experts in AI-Enhanced Toxicology ](https://www.onesumportal.com/articles-news/articles/the-central-role-of-experts-in-ai-enhanced-toxicology) - [ What is Onesum? ](https://www.onesumportal.com/articles-news/articles/what-is-onesum) ### Systematic Reviews Our **AI-supported, protocol-driven workflows** enable structured and comprehensive systematic reviews of toxicological data. AI automation enhances search efficiency and coverage, while expert oversight ensures **accurate interpretation and traceability** throughout the process. This combination delivers **well-structured, evidence-based syntheses** that support regulatory submissions and risk assessments. You can read more about these approaches and solutions in the following articles: - [ The Central Role of Experts in AI-Enhanced Toxicology ](https://www.onesumportal.com/articles-news/articles/the-central-role-of-experts-in-ai-enhanced-toxicology) - [ What is Onesum? ](https://www.onesumportal.com/articles-news/articles/what-is-onesum) ### Read-Across Justification Our **AI-enhanced read-across services** integrate toxicological expertise with computational analysis across structural, physicochemical, metabolic, and toxicological domains. AI supports **analog search, similarity assessment, and the automated collection and evaluation of analogue data**, ensuring efficient and comprehensive data coverage. This process is complemented by expert toxicological review and uncertainty analysis, resulting in **transparent, regulator-ready justifications** that provide **robust, science-based alternatives** to traditional testing. You can read more about these approaches and solutions in the following articles: - [ The Central Role of Experts in AI-Enhanced Toxicology ](https://www.onesumportal.com/articles-news/articles/the-central-role-of-experts-in-ai-enhanced-toxicology) - [ What is Onesum? ](https://www.onesumportal.com/articles-news/articles/what-is-onesum) ### Onesum Platform Our specialized **AI-assisted service** applies our software technology to **accelerate toxicological risk assessment**. The approach can be tailored to specific project needs, enabling targeted support where automation provides the greatest value. Through controlled use of large language models, we support search, literature review, data extraction, and evidence summarization, while toxicologists retain full control of knowledge sources and task execution. A human-in-the-loop approach ensures expert validation throughout, improving efficiency without compromising accuracy, reproducibility, or accountability in final decisions. You can read more about these approaches and solutions in the following articles: - [ What is Onesum? ](https://www.onesumportal.com/articles-news/articles/what-is-onesum) ## Schema ```json { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.onesumportal.com" }, { "@type": "ListItem", "position": 2, "name": "Solutions", "item": "https://www.onesumportal.com/solutions" } ] } ``` ```json { "@context": "https://schema.org", "@type": "Service", "name": "High quality toxicology assessments: fast, affordable, expert-led, and regulatory compliant.", "serviceType": "High quality toxicology assessments: fast, affordable, expert-led, and regulatory compliant.", "description": "Onesum’s experienced team is ready to solve your complex toxicological risk assessment reporting challenges, combining our proprietary AI platform with scientific and regulatory expertise to deliver trusted, high-quality reports quickly and cost-effectively.", "image": "https://www.onesumportal.com/images/News/bridging.jpg", "url": "https://www.onesumportal.com/solutions", "provider": { "@type": "Organization", "name": "Onesum", "image": "https://www.onesumportal.com/images/Onesum_Color.png", "address": { "@type": "PostalAddress", "addressCountry": "IT" } }, "offers": { "@type": "Offer", "price": "0.00", "priceCurrency": "USD" } } ```